Clinically proven to stop muscle cramps in 60 seconds. Pickle Juice interacts with receptors in the throat to stop the overactive nerve signals from the brain that cause muscles to lock up. 100% natural. Innovation that works. Take one serving (2.5 oz shot) at the onset of a muscle cramp for relief within 60 seconds. If taken preventatively, use before your activity to stay cramp free for up to 45 minutes.